Institute for Ethics and Emerging Technologies



Technoprogressive? BioConservative? Huh?
Quick overview of biopolitical points of view



UPCOMING EVENTS: Maria Konovalenko

New Worlds 2015
October 16-17
Austin TX USA




MULTIMEDIA: Maria Konovalenko Topics

The dilemma of human enhancement

Longevity Cook Book

Open Source Biotech: Fund Anti-Cancer Research and Make Drugs Cheaper at the Same Time

Achieving Personal Immortality Roadmap

Recent News on Longevity and Health

Can We Live Forever – a Cool Video From the Advanced Apes

Roadmap to Immortality – Artificial Intelligence

Roadmap to Immortality – Nanomedicine

Roadmap to Immortality – Cyborgization, and Cryonics

Craig Venter Decided to Beat Calico in the Race towards Human Life Extension

Projects to accelerate radical healthy longevity

Robert Shmookler Reis on Fighting Aging Approaches and Role of Basic Science

Dark Matter of Transhumanism

Second Transhumanist Political Meeting in Moscow




Subscribe to IEET Lists

Daily News Feed

Longevity Dividend List

Catastrophic Risks List

Biopolitics of Popular Culture List

Technoprogressive List

Trans-Spirit List









Maria Konovalenko Topics




A Possible Way to Cure Baldness

by Maria Konovalenko

There is something important going on in the fight against baldness.

As in the majority of tissues, the hair follicle has stem cells. There are two types of stem cells that are responsible for the continuous renewal of the follicles. The first type is called active stem cells and they start dividing quite easily. Stem cells of the second type are called quiescent and in case of the new hair growth they don’t start dividing as easily. At the same time, the new hair is based primarily on quiescent cells, which attracted close attention of researchers to these cells. At first people thought that baldness was due to this type of cells. 

Full Story...



The mTOR Story Part 1 – What Makes This Important Pro-Aging Molecule Active?

by Maria Konovalenko

I have mentioned mTOR as one of the main aging genes on multiple occasions. It’s about time I tell you what it is, what it does and why it is so important in aging.

mTOR has a little m in front of TOR, which means I am speaking about mammals. It technically means «mechanistic» TOR, but think of it as the molecule that mice and all of us have, whereas in worms is it just TOR.

Full Story...



It is Unethical Not to Use Genetic Engineering

by Maria Konovalenko

When I hear that the conversation is about an ethical problem I anticipate that right now the people are going to put everything upside down and end with common sense. Appealing to ethics has always been the weapon of conservatism, the last resort of imbecility.

Full Story...



Fighting Death with “The Longevity Cookbook”

by Maria Konovalenko

The most significant event in a person’s life is death. It changes everything. More precisely, it takes everything that a person had. If he was in love, he no longer is. If he was aspiring to pleasures, there will be none any longer. The world will be gone for the person.

Every single neuron will disappear that was responsible for the wishes, desires, and feelings. We don’t realize this, but everything single thing we accomplish, we do so looking in the face of inevitable death. Death takes away the sense of a person’s life.

Full Story...



Transhumanism Strategy Boils Down to Choosing a Crowdfunding Project

by Maria Konovalenko

First of all, let’s draw a line between a strategy and wishful thinking. There are plenty of wonderful transhumanist projects. A viral video, a global portal, attracting celebrities, proof that aging is a disease, convincing billionaires, educational programs, letters to politicians, civil actions, participating in elections, creating a strong community, clinical trials of combinations of existing age delaying drugs on animals, TV shows, Hollywood blockbusters, creating a political committee, conferences on transhumanist topics, scientific megaproject on life extension, cryonics company, crowdfunding, a lot of startups relevant to transhumanist topics, active use of AI elements in all areas and so on .



Transhumanism Strategy

by Maria Konovalenko

We’ve put together the survey on transhumanism strategy to reveal the inner discussion inside the transhumanist movement. Our goal is to inspire the people to act. We believe the greatest sin in our field is wishful thinking. It’s when a person is saying that it would be good to do something, like for instance, to shoot a viral video, but at the same time this person is not doing anything. His or hers advice has to be implemented in real life somehow on its own.



Cure for Aging Can Be Created Using Directed Evolution

by Maria Konovalenko

Accumulating evidence suggests that microbiota plays an important role in modulating lifespan. This makes possible to use symbiotic bacteria as “living drugs”, which live in the host organism and promote its longevity. We propose to create bacteria, which dramatically extend lifespan of its host. Such bacteria have to produce not one, but a set of longevity-promoting substances with optimal concentrations and dynamics of secretion. To obtain such bacteria we propose to use directed evolution, a process that mimics Darwinian selection on a laboratory scale.



Longevity Gene Therapy – Updated Projects

by Maria Konovalenko

While discussing the longevity gene therapy project we encountered various questions and observations that prompted us to broaden the project and slightly change it. Generally, all the comments can be reduced into 5 main points…



Popular Lectures on Gene Therapy

by Maria Konovalenko

Maria Konovalenko and team put together a list of popular science video lectures on gene therapy – one of the most promising molecular medicine directions. What makes this approach different is that nucleic acid molecules, DNA and RNA, are used as therapeutic agents.



We Can Learn a Lot from Yeast How to Slow Down Aging

by Maria Konovalenko

Dr. Valter Longo hold the record of yeast lifespan extension. He was able to increase longevity of this species 10 fold. This a one of the most remarkable results in longevity science. Here Dr. Longo is giving us a lecture on yeast genetics. Let me summarize what he told us.



Role of Mitochondria in Disease

by Maria Konovalenko

There are tree lectures about the mitochondria in my course. Dr. Pinchas Cohen, the Dean of Davis School of Gerontology, talked about the role of mitochondria in disease and pathology. Mitochondria have essentially three major functions. They are responsible for cellular respiration, integration of apoptotic signals, which means they control cell death, and production of reactive oxygen species (ROS). Mitochondrial function declines with age as a result of accumulated mutations in the mitochondrial DNA. Mitochondrial disfunction is common in diseases, such as diabetes, neurodegenerative pathologies and cancer.



How to Win the Palo Alto Longevity Prize

by Maria Konovalenko

$1,000,000 is the recently announced prize by Joon Yun, a Palo Alto-based entrepreneur, who is willing to donate this amount of money as an incentive to end aging. Half of the million will be given to the team of researchers who are able to extend lifespan by 50% in a model animal, and the other half – to those who manage to “demonstrate that it can restore homeostatic capacity (using heart rate variability as the surrogate measure) of an aging reference mammal to that of a young adult.”



Longevity Gene Therapy Is the Best Way to Defeat Aging

by Maria Konovalenko

Gene engineering is the most powerful existing tool for life extension. Mutations in certain genes result in up to 10-fold increase in nematode lifespan and in up to 2-fold increase in a mouse life expectancy. Gene therapy represents a unique tool to transfer achievements of gene engineering into medicine. This approach has already been proven successful for treatment of numerous diseases, in particular those of genetic and multigenic nature. More than 2000 clinical trials have been launched to date.



Mitochondria and its role in aging

by Maria Konovalenko

Today was an amazing lecture by Dr. David Lee about mitochondria and its role in aging. Dr. Lee started with an overview of what mitochondria is and what it does. You may have heard that the origin of mitochondria is bacteria that was engulfed by the cell early in the course of evolution.



Hollywood Must Turn Its Head to Personalized Longevity Science instead of Anti-Aging Pseudoremedies

by Maria Konovalenko

This attention-worthy article in The Hollywood Reporter signals that Hollywood people are ready and willing to do something about their longevity. The article mentions hormone replacement therapy, different check-ups and other things available in California, however completely misses 99% of what actually can be done about aging – science.



Biology and Biology of Aging Resources (6 videos)

by Maria Konovalenko

We have prepared a list of resources that can help understand biology of aging. We tried to find easy to grasp information sources and compiled a list of lectures, audio courses, popular science books and articles on biology in general and biology of aging in particular. The selected resources probably don’t exhaust the whole picture of aging science, but they shed light on the main ideas and research directions in this area.



Let’s Bet on Money?

by Maria Konovalenko

Let’s make a bet? I will propose something incredibly effective in the area of life extension and no one will be able to suggest a better strategy. Deal?



9 Obvious Steps to Immortality

by Maria Konovalenko

Maria Konovalenko discusses personalized medicine services, why you should participate in clinical trials of geroprotector drug candidates,  Personalized science, Why scientific research should be organized, why you should be friends with people with no harmful habits,  “Create crowdfunding campaigns in the area of longevity”, why you should increase your own competence, promote the value of human longevity, and neuropreservation.



What Should Be Done to Achieve Radical Life Extension?

by Maria Konovalenko

Theoretically the problem is already solved. It is now quite obvious what kind of research should be done for life extension. For example, testing various combinations of different things that extend lifespan in old mice. Particularly important is longevity gene therapy development.



Third International “Genetics of Aging and Longevity” Conference

by Maria Konovalenko

More than 200 participants from North America, Europe and Asia met in post-Olympic Sochi for five days this April, as world-famous anti-aging researchers exchanged ideas at the third International Conference on Genetics of Aging and Longevity. They discussed progress and remaining obstacles, in their efforts to deepen our understanding of this complex phenomenon and develop strategies for interventions.



Roadmap to Immortality: Genetic, Regenerative Medicine, and Digital

by Maria Konovalenko

Maria Konovalenko presents us with 3 beautiful images of important life extension sciences. They include topics such as evaluating drug efficacy based on aging and longevity makers, studying our genetic makeup, genomics, genetic mathematical models, growing new bodies, stem cells, hematopoiesis, stimulating nerve tissue, better brain to computer interfaces, computer models of working nervous systems, full map of the human brain, to uploading ones mind to a computer platform.



Life Extension is a Political Task

by Maria Konovalenko

Sooner or later the human life extension problem, the task of achieving immortality will become the main issue of government policies in developed countries of the world. This will happen on its own because of the exponential growth of technologies. At some point of time immortality will become the main political question. This is inevitable.



#7 There Can Be No Healthy Aging

by Maria Konovalenko

The study, conducted by a team of scientists and clinicians from JCVI and WCHN, will focus on two groups of elderly individuals aged 65 to 85 years by correlating genetics with a variety of human genomic, gut microbiome and other “omics” profiles and integrating these data with the individuals’ health record. One group will consist of healthy individuals, and the other will have individuals with a variety of diagnosed health conditions.



#17 A Letter to Sergey Brin

by Maria Konovalenko

I’ve heard you are interested in the topics of aging and longevity. This is very cool, because fighting for radical life extension is the wisest and most humanitarian strategy. I would like to tell you what needs to be done, but, unfortunately, I haven’t got your email address, or any other way to be heard.



“You May not Die” Exhibit Starts December 9th in Marat Guelman’s Gallery in Moscow

by Maria Konovalenko

One of the best art galleries in Moscow is going to host the first art exhibition about radical life extension – “You may not die”. This message is addressed primarily to the artistic community, and is a proposal for cooperation – let’s stand together and convince people that we have the opportunity to stay alive.



Don’t Drag Me Along into Your Grave, Daniel Callahan

by Maria Konovalenko

I don’t want to die, but apparently Daniel Callahan wants me to.  He wants me to say nothing, do nothing about aging and just wait until I am 75 and die quietly. Well, that’s not going to happen, mister. Bioethicisits like Callahan are the ones responsible for our suffering from the horrors of aging-related diseases and death. And here’s why. The opinion of bioethicists prevents the progress from being fast enough to cure aging. The decision-makers rely upon what senior “thinkers” like Callahan have in mind on the problem of life extension.



There Can Be No Healthy Aging

by Maria Konovalenko

The study, conducted by a team of scientists and clinicians from JCVI and WCHN, will focus on two groups of elderly individuals aged 65 to 85 years by correlating genetics with a variety of human genomic, gut microbiome and other “omics” profiles and integrating these data with the individuals’ health record. One group will consist of healthy individuals, and the other will have individuals with a variety of diagnosed health conditions.



Google’s Calico – Maybe Not Such a Good News

by Maria Konovalenko

On September 18 Google announced their crusade against death via the Time journal cover. Calico company was created specifically to fight aging. Larry page made it clear for the shareholders that Google is an innovative company and that they can afford the most courageous projects, while the investments won’t be too large and won’t undermine the foundations of the company.



We Should All Follow Michelle’s Example

by Maria Konovalenko

My friend Michelle has done something very important and very useful to all of us – she donated money to aging research. I believe this is how we can change the situation – by following Michelle’s example.



A Letter to Sergey Brin

by Maria Konovalenko

I’ve heard you are interested in the topics of aging and longevity. This is very cool, because fighting for radical life extension is the wisest and most humanitarian strategy. I would like to tell you what needs to be done, but, unfortunately, I haven’t got your email address, or any other way to be heard.

Page 1 of 2 pages  1 2 > 

HOME | ABOUT | FELLOWS | STAFF | EVENTS | SUPPORT  | CONTACT US
SECURING THE FUTURE | LONGER HEALTHIER LIFE | RIGHTS OF THE PERSON | ENVISIONING THE FUTURE
CYBORG BUDDHA PROJECT | AFRICAN FUTURES PROJECT | JOURNAL OF EVOLUTION AND TECHNOLOGY

RSSIEET Blog | email list | newsletter |
The IEET is a 501(c)3 non-profit, tax-exempt organization registered in the State of Connecticut in the United States.

Contact: Executive Director, Dr. James J. Hughes,
56 Daleville School Rd., Willington CT 06279 USA 
Email: director @ ieet.org     phone: 860-297-2376