There are tree lectures about the mitochondria in my course. Dr. Pinchas Cohen, the Dean of Davis School of Gerontology, talked about the role of mitochondria in disease and pathology. Mitochondria have essentially three major functions. They are responsible for cellular respiration, integration of apoptotic signals, which means they control cell death, and production of reactive oxygen species (ROS). Mitochondrial function declines with age as a result of accumulated mutations in the mitochondrial DNA. Mitochondrial disfunction is common in diseases, such as diabetes, neurodegenerative pathologies and cancer.
The “Singularity” seems to have become a new lucrative field for the struggling publishing industry (and, i am sure, soon, for the equally struggling Hollywood movie studios). To write a bestseller, you have to begin by warning that machines more intelligent than humans are coming soon. That is enough to get everybody’s attention.
Diet and genomes interact due to the simple fact that nutrition is perhaps the most important environmental factor in human development. The food we eat is the fundamental factor defining our optimal state of health and mental capacity.
Chief Operations Officer Andy Zawacki guides us through a tour of the Cryonics Institute (CI) facility as well as the whole process of cryo-preservation – from the moment that legal death is declared to the moment patients are placed in long term storage.
On September 23, the Food and Drug Administration sent Rima Laibow and Ralph Fucetola at the Natural Solutions Foundation a warning letter claiming that their allegedly nano (colloidal) silver based “Dr. Rima Recommends™ The Silver Solution” product violates the Federal Food, Drug, and Cosmetic Act (FFDC Act).
Reproducing in space, lifeboat problems, and other ethical quandaries that could arise if we travel to Mars. Disaster can happen at any moment in space exploration. “A good rule for rocket experimenters to follow is this: always assume that it will explode,” the editors of the journal Astronautics wrote in 1937, and nothing has changed: This August, SpaceX’s rocket blew up on a test flight.
We have a pretty good sense of how digestion works. And our grasp of thermodynamics is excellent. We know that there are three bones – the smallest in our bodies – in the middle ear, and that stars produce light because of thermonuclear fusion. While I’m skeptical of “progressionist” claims that the human condition has inexorably improved since the Neolithic revolution (the proliferation of technology-related existential risks being one reason for skepticism), it seems that science has made genuine progress.
The first ever comprehensive introduction edited by Robert Ranisch and IEET Fellow Stefan Lorenz Sorgner which compares and contrasts posthumanism and transhumanism is forthcoming within the next two weeks.
$1,000,000 is the recently announced prize by Joon Yun, a Palo Alto-based entrepreneur, who is willing to donate this amount of money as an incentive to end aging. Half of the million will be given to the team of researchers who are able to extend lifespan by 50% in a model animal, and the other half – to those who manage to “demonstrate that it can restore homeostatic capacity (using heart rate variability as the surrogate measure) of an aging reference mammal to that of a young adult.”
Suspended Animation is a mean to preserve life by slowing or halting its processes, while not causing death. This is similar to natural occurring anabiosis, though carried out artificially in order to preserve human and non-beings. Currently there are two main means of suspended animation, Cryopresevation, dubbed Cryonics, and the less developed Ahydrobiosis. The former uses low temperatures or chemical fluid replacements, while the former uses desiccation in order to preserve an organism.
The only revolution is the communications revolution. Every other change of significance sits on top of it, and is one or other expression of it. Ideas preserved in stone, even literally in stone, means that insights can compound. Understanding can build upon itself, can grow deeper and deeper.
Robert Frost’s famous imagery—fire or ice, take your pick—pretty much sums it up. But lately, largely unnoticed, a revolution has unwound in the thinking about such matters, in the hands of that most rarefied of tribes, the theoretical physicists. Maybe, just maybe, ice isn’t going to be the whole story. Of course, linking the human prospect to cosmology itself is not at all new. The endings of stories are important, because we believe that how things turn out implies what they ultimately mean. This comes from being pointed toward the future, as any ambitious species must be.
In an age of unlimited access to information, coupled with an endless bombardment of stimulation from technology, I find it important to reassess our notions of bringing balance to what it means to be focused and present.
Earlier this year, the first mind-to-mind communication took place. Hooked up to brain wave headsets, a researcher in India projected a thought to a colleague in France, and they understood each other. Telepathy went from the pages of science fiction to reality.
Several years ago, Bill Gates keynoted a breakfast for Seattle-based Climate Solutions, a nonprofit focused on advancing the clean energy economy and driving practical, profitable solutions to climate change. Gates opened his speech with an equation. To paraphrase: Our carbon problem = persons x services x the energy intensity of services x the carbon intensity of energy. The number of people is growing, Gates observed, and we all want more services.
Consider the following passage from Richard Dawkins’s book Unweaving the Rainbow: “We are going to die, and that makes us the lucky ones. Most people are never going to die because they are never going to be born. The potential people who could have been here in my place but who will in fact never see the light of day outnumber the sand grains of Arabia. Certainly those unborn ghosts include greater poets than Keats, scientists greater than Newton. We know this because the set of possible people allowed by our DNA so massively exceeds the set of actual people…”
This time, let’s veer into an area wherein I actually know a thing or two! The matter of whether humanity might someday… or even should… meddle in other creatures on this planet and bestow upon them the debatable “gift” of full sapience—the ability to argue, ponder, store information, appraise, discuss, create, express and manipulate tools, so that they might join us in the problematic task of being worthy planetary managers.
Gene engineering is the most powerful existing tool for life extension. Mutations in certain genes result in up to 10-fold increase in nematode lifespan and in up to 2-fold increase in a mouse life expectancy. Gene therapy represents a unique tool to transfer achievements of gene engineering into medicine. This approach has already been proven successful for treatment of numerous diseases, in particular those of genetic and multigenic nature. More than 2000 clinical trials have been launched to date.
Today was an amazing lecture by Dr. David Lee about mitochondria and its role in aging. Dr. Lee started with an overview of what mitochondria is and what it does. You may have heard that the origin of mitochondria is bacteria that was engulfed by the cell early in the course of evolution.
A History of Life-Extensionism in the Twentieth Centuryby Ilia Stambler is the most thorough treatment to date of the ideas of famous thinkers and scientists who attempted to prolong human lifespans. In this detailed and impressively documented work – spanning 540 pages – Dr. Stambler explores the works of life-extensionist thinkers and practitioners from a vast variety of ideological, national, and methodological backgrounds.
This attention-worthy article in The Hollywood Reporter signals that Hollywood people are ready and willing to do something about their longevity. The article mentions hormone replacement therapy, different check-ups and other things available in California, however completely misses 99% of what actually can be done about aging – science.
We have prepared a list of resources that can help understand biology of aging. We tried to find easy to grasp information sources and compiled a list of lectures, audio courses, popular science books and articles on biology in general and biology of aging in particular. The selected resources probably don’t exhaust the whole picture of aging science, but they shed light on the main ideas and research directions in this area.
On March 26, 2014, there took place in BarIlanUniversity the conference entitled – “Biology of Longevity and Quality of Life” which was also widely promoted under the title “Pathways to Healthy Longevity”. The conference was held as a part of the celebrations of Israel Science Day, under the auspices of the Israel Ministry of Science.
If the controversy over genetically modified organisms (GMOs) tells us something indisputable, it is this: GMO food products from corporations like Monsanto are suspected to endanger health. On the other hand, an individual’s right to genetically modify and even synthesize entire organisms as part of his dietary or medical regimen could someday be a human right.
I’ve been writing about the ethics of human enhancement for some time. In the process, I’ve looked at many of the fascinating ethical and philosophical issues that are raised by the use of enhancing drugs. But throughout all this writing, there is one topic that I have studiously avoided. This is surprising given that, in many ways, it is the most fundamental topic of all: do the alleged cognitive enhancing drugs actually work?
“This year alone, there have been 17,000 cases of meningitis in Nigeria, with nearly 1,000 deaths”. It’s a statement that jumped out at me watching a video from this summer’s Aspen Ideas Festival by my former University of Michigan Public Health student Utibe Effiong.
The paper tries to fuse traditional concerns about the problem of evil with recent work in population ethics. The result is an interesting, and somewhat novel, atheological argument. As is the case with every journal club, I will try to kick start the discussion by providing an overview of the paper’s main arguments, along with some questions you might like to ponder about its effectiveness.
I'm back from the first Climate Engineering Conference, held in Berlin. Quite a good trip, but in many ways the highlight was the talk I gave at the Berlin Natural History Museum. The gathering took place in the dinosaur room, which holds (among other treasures) the "Berlin Specimen" Archaeopteryx fossil, among the most famous and most important fossils ever discovered.
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