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Table of Contents
00:00 - Introduction
00:44 - Structure of the brain
03:45 - Developing new tools with synthetic biology
05:35 - Current methods of neuron stimulation
09:10 - New method: using light to control neurons
15:31 - Demonstration: neuron control in a mouse
17:07 - Controlling the dopamine system of a mouse
20:06 - Tracing genetic mutations to mental disease
21:50 - Molecular tools for studying mutations
29:29 - Using genome editors to repair mutations
33:54 - Applying genome editors outside of medicine
35:30 - Conclusion
36:30 - Q&A
Analyzing patterns of gene activity during brain development will surely transform scientists’ understanding of neuropsychiatric diseases. In his 2012 Midsummer Nights’ Science lecture, Feng Zhang discusses the invention of novel technologies for genome engineering, and for manipulating activities of different cell types, including neurons. Current applications of these techniques include molecular investigations of processes as diverse as motor function, the reward system, and sleep.
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The IEET is a 501(c)3 non-profit, tax-exempt organization registered in the State of Connecticut in the United States.
Contact: Executive Director, Dr. James J. Hughes,
Williams 119, Trinity College, 300 Summit St., Hartford CT
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