I have had thoughts about quantum mechanics and biology for many years - ever since my thermodynamics class in chemistry as an undergrad. I discussed and developed them over the years. When I thought it was ready, decades ago, I wrote to Linus Pauling about my speculation that the most important differentiator for life is that from the molecular scale to the organization of organs, chaos (in the mathematical chaos theory sense) is the organizing principle. This means that living organisms are all potentially sensitive to quantum events. He w...
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Is metformin safe? The dose for the metformin aging clinical trial is 1700 mg per day. The mouse study doses from the graphs below are 300 and 100 mg/kg/day. Assuming an average 60 kg person, that’s about 28 mg/kg. This is about one-third to one-tenth the dose that mice got.
In graduate school I was warned not to touch anything to do with homosexuality or transgenderism. By that time I had learned that graduate school and high end science was not the open-minded inquiry I had expected. I was, however, convinced then that most transexuals were in part biologically female.
A much better metaphor for gene therapy is space-alien hackers attacking a huge factory covering San Francisco. These hackers shoot canisters of paper-tape instructions for the old computer controlled machinery into this billion year old factory.
Much is being made recently about telomerase as the cure for what ails you. Activating telomerase is touted by Bioviva as a supposed cure for Alzheimer’s disease. (In fact, the article referenced advances an hypothesis.) A PR announcement that appears related has appeared.
Three new positions have been filled at IEET, in two categories: our Affiliate Scholar Program, which we’ve maintained for a decade, and our Advisory Board - which was installed just last May.
I have been pursuing gene therapies for aging, so my decision to discuss this goes against my current direction. We really don’t know what the limits are of what we might be able to do by playing the autonomic nervous system, but here are some thoughts to chew on.
The human brain is large, but 90% of your nervous system is outside your head. Researchers have found that interrupting vagus nerve signals to the brain can treat rheumatoid arthritis, as well as septic shock symptoms, however, some body subsystems may, or may n...
We evolved to die. Our thymus involutes (withers away) in large part due to down-regulation of FoxN1. Once the thymus goes, it’s just a matter of time. Critical mitochondrial genes, GCAT & SHMT2, are turned off, and that causes oxidation damage that we interpreted as the cause of mitochondrial aging when it’s really the outcome. Upregulation ofATF4 expression results in muscle loss in aging. This list will lengthen the more we learn. Aging and death is no accident. It’s got value.
The singularity is not going to do away with humanity. If there is one, we will be at the center of it. We will be the singularity, together.
Today we are doing brain stem stimulation for treating Parkinson’s disease. Vagus nerve stimulation stops rheumatoid arthritis and can control other immune activity. Cortical arrays pick up brain activity allowing control of robot arm and decoding of speech. Rejection and scarring are problems with electrodes, but recent advances in injectable micro-electrodes and flexible, stretcha...