Aging has been slowed and healthy lifespan prolonged in many disparate animal models (C. elegans, Drosophila, Ames dwarf mice, etc.). Thus, assuming there are common fundamental mechanisms, it should also be possible to slow aging in humans.
Greater knowledge about aging should bring better management of the debilitating pathologies associated with aging, such as cancer, cardiovascular disease, type II diabetes, and Alzheimer’s. Therapies targeted at the fundamental mechanisms of aging will be instrumental in counteracting these age-related pathologies.
Therefore, this letter is a call to action for greater funding and research into both the underlying mechanisms of aging and methods for its postponement. Such research may yield dividends far greater than equal efforts to combat the age-related diseases themselves. As the mechanisms of aging are increasingly understood, increasingly effective interventions can be developed that will help prolong the healthy and productive lifespans of a great many people.
Valter Longo, Ph.D.
Professor and researcher at the University of Southern California Leonard Davis School of Gerontology, Assistant Professor of Gerontology and Biological Science, Cell Biology and genetics, regulation of aging and multiple stress resistance systems in yeast and mammals, Alzheimer’s Disease.
Brian J. Morris, Ph.D.
Professor of Molecular Medical Sciences in the School of Medical Sciences of the Faculty of Medicine at The University of Sydney; has over 230 publications; research focusing on the alteration in genome-wide expression profiles during ageing of human cells. [10/116/05]
Robert J. Shmookler Reis, Ph.D.
Professor, Depts. of Geriatrics, Medicine, Biochemistry & Molec.Biol., and Pharmacology; University of Arkansas for Medical Sciences and Career Health Scientist, Central Arkansas Veterans Healthcare Service.
Ben Goertzel, Ph.D.
Ph.D. in Mathematics from Temple University; Chief Scientific Officer, Biomind LLC, creating AI-based software for the analysis of gene expression data.
Amara Graps, Ph.D.
Ph.D. in Astrophysics from the University of Heidelberg, Germany; Planetary scientist at the Institute of the Physics of Interplanetary Space in Rome, Italy; Published articles on astronomical dust physics and charging and scientific computing.
Sergey V. Sheleg, M.D., Ph.D.,
Chief Research Scientist, Alcor Life Extension Foundation; M.D. from the Belarus State Medical University and Ph.D. in Oncology from N.N. Alexandrov Research Institute of Oncology and Medical Radiology (Lesnoy, Belarus). More than 20 published papers in the fields of neuro-oncology, neuro-infectious diseases, brain anoxia, and molecular cell biology